1CD5

GLUCOSAMINE-6-PHOSPHATE DEAMINASE FROM E.COLI, T CONFORMER

1CD5 の概要

• エントリーDOI: 10.2210/pdb1cd5/pdb
• 分子名称: PROTEIN (GLUCOSAMINE 6-PHOSPHATE DEAMINASE) (2 entities in total)
• 機能のキーワード: allosteric enzyme, entropic effects, aldose-ketose isomerase, isomerase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29812.21

構造登録者

Horjales, E.,Altamirano, M.M.,Calcagno, M.L.,Garratt, R.C.,Oliva, G. (登録日: 1999-03-05, 公開日: 2000-03-06, 最終更新日: 2023-08-09)

主引用文献

Horjales, E.,Altamirano, M.M.,Calcagno, M.L.,Garratt, R.C.,Oliva, G.
The allosteric transition of glucosamine-6-phosphate deaminase: the structure of the T state at 2.3 A resolution.
Structure Fold.Des., 7:527-537, 1999

PubMed Abstract: The allosteric hexameric enzyme glucosamine-6-phosphate deaminase from Escherichia coli catalyses the regulatory step of N-acetylglucosamine catabolism, which consists of the isomerisation and deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonia. The reversibility of the catalysis and its rapid-equilibrium random kinetic mechanism, among other properties, make this enzyme a good model for studying allosteric processes.

PubMed: 10378272
DOI: 10.1016/S0969-2126(99)80069-0

実験手法

X-RAY DIFFRACTION (2.3 Å)