1CD1

CD1(MOUSE) ANTIGEN PRESENTING MOLECULE

Summary for 1CD1

• Entry DOI: 10.2210/pdb1cd1/pdb
• Descriptor: CD1 (2 entities in total)
• Functional Keywords: cd1, immunology, mhc, tcr, glycoprotein, immunoglobulin fold, t-cell
• Biological source: Mus musculus (house mouse); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P11609; Secreted: P01887
• Total number of polymer chains: 4
• Total formula weight: 95456.59

Authors

Zeng, Z.H.,Segelke, B.W.,Wilson, I.A. (deposition date: 1997-04-02, release date: 1997-10-15, Last modification date: 2024-04-03)

Primary citation

Zeng, Z.,Castano, A.R.,Segelke, B.W.,Stura, E.A.,Peterson, P.A.,Wilson, I.A.
Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove.
Science, 277:339-345, 1997

PubMed Abstract: CD1 represents a third lineage of antigen-presenting molecules that are distantly related to major histocompatibility complex (MHC) molecules in the immune system. The crystal structure of mouse CD1d1, corresponding to human CD1d, at 2.8 resolution shows that CD1 adopts an MHC fold that is more closely related to that of MHC class I than to that of MHC class II. The binding groove, although significantly narrower, is substantially larger because of increased depth and it has only two major pockets that are almost completely hydrophobic. The extreme hydrophobicity and shape of the binding site are consistent with observations that human CD1b and CD1c can present mycobacterial cell wall antigens, such as mycolic acid and lipoarabinomannans. However, mouse CD1d1 can present very hydrophobic peptides, but must do so in a very different way from MHC class Ia and class II molecules.

PubMed: 9219685
DOI: 10.1126/science.277.5324.339

Experimental method

X-RAY DIFFRACTION (2.67 Å)