1C8L

SYNERGISTIC INHIBITION OF GLYCOGEN PHOSPHORYLASE A BY A POTENTIAL ANTIDIABETIC DRUG AND CAFFEINE

1C8L の概要

• エントリーDOI: 10.2210/pdb1c8l/pdb
• 分子名称: PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 2,3-DICARBOXY-4-(2-CHLORO-PHENYL)-1-ETHYL-5-ISOPROPOXYCARBONYL-6-METHYL-PYRIDINIUM, ... (6 entities in total)
• 機能のキーワード: glycogen metabolism, diabetes, phosphorylase a, synergistic inhibition, allosteric site, inhibitor site, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98311.44

構造登録者

Tsitsanou, K.E.,Skamnaki, V.T.,Oikonomakos, N.G. (登録日: 2000-05-16, 公開日: 2000-05-31, 最終更新日: 2023-08-09)

• 主引用文献: Tsitsanou, K.E.,Skamnaki, V.T.,Oikonomakos, N.G.; Structural basis of the synergistic inhibition of glycogen phosphorylase a by caffeine and a potential antidiabetic drug.; Arch.Biochem.Biophys., 384:245-254, 2000; PubMed: 11368311; DOI: 10.1006/abbi.2000.2121

実験手法

X-RAY DIFFRACTION (2.3 Å)