1C70

ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP.

1C70 の概要

• エントリーDOI: 10.2210/pdb1c70/pdb
• 関連するPDBエントリー: 1c6x 1c6y 1c6z
• 分子名称: PROTEIN (PROTEASE), N-[2(R)-HYDROXY-1(S)-INDANYL]-2(R)-PHENYLMETHYL-4(S)-HYDROXY-5-[4-[2-BENZOFURANYLMETHYL]-2(S)-[TERT-BUTYLAMINOCARBONYL]-PIPERAZINYL]-PENTANEAMIDE (3 entities in total)
• 機能のキーワード: hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22260.33

構造登録者

Munshi, S. (登録日: 1999-12-29, 公開日: 2000-12-28, 最終更新日: 2023-12-27)

• 主引用文献: Munshi, S.,Chen, Z.,Yan, Y.,Li, Y.,Olsen, D.B.,Schock, H.B.,Galvin, B.B.,Dorsey, B.,Kuo, L.C.; An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease.; Acta Crystallogr.,Sect.D, 56:381-388, 2000; PubMed: 10739910; DOI: 10.1107/S0907444900000469

実験手法

X-RAY DIFFRACTION (2.5 Å)