1C6W

MAUROCALCIN FROM SCORPIO MAURUS

1C6W の概要

• エントリーDOI: 10.2210/pdb1c6w/pdb
• 分子名称: MAUROCALCIN (1 entity in total)
• 機能のキーワード: scorpion toxin, ryanodine receptor effector, toxin
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 3876.69

構造登録者

Mosbah, A.,Kharrat, R.,Fajloun, Z.,Renisio, J.-G.,Blanc, E.,Sabatier, J.-M.,Ayeb, M.,Darbon, H. (登録日: 1999-12-23, 公開日: 2000-09-06, 最終更新日: 2024-11-13)

主引用文献

Mosbah, A.,Kharrat, R.,Fajloun, Z.,Renisio, J.G.,Blanc, E.,Sabatier, J.M.,El Ayeb, M.,Darbon, H.
A new fold in the scorpion toxin family, associated with an activity on a ryanodine-sensitive calcium channel.
Proteins, 40:436-442, 2000

PubMed Abstract: We determined the structure in solution by (1)H two-dimensional NMR of Maurocalcine from the venom of Scorpio maurus. This toxin has been demonstrated to be a potent effector of ryanodyne-sensitive calcium channel from skeletal muscles. This is the first description of a scorpion toxin which folds following the Inhibitor Cystine Knot fold (ICK) already described for numerous toxic and inhibitory peptides, as well as for various protease inhibitors. Its three dimensional structure consists of a compact disulfide-bonded core from which emerge loops and the N-terminus. A double-stranded antiparallel beta-sheet comprises residues 20-23 and 30-33. A third extended strand (residues 9-11) is perpendicular to the beta-sheet. Maurocalcine structure mimics the activating segment of the dihydropyridine receptor II-III loop and is therefore potentially useful for dihydropyridine receptor/ryanodine receptor interaction studies. Proteins 2000;40:436-442.

PubMed: 10861934
DOI: 10.1002/1097-0134(20000815)40:3<436::AID-PROT90>3.0.CO;2-9

実験手法

SOLUTION NMR