1C3M

CRYSTAL STRUCTURE OF HELTUBA COMPLEXED TO MAN(1-3)MAN

1C3M の概要

• エントリーDOI: 10.2210/pdb1c3m/pdb
• 関連するBIRD辞書のPRD_ID: PRD_900112
• 分子名称: AGGLUTININ, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose (3 entities in total)
• 機能のキーワード: agglutinin, jacalin-related, beta-prism, mannose, sugar binding protein
• 由来する生物種: Helianthus tuberosus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15843.77

構造登録者

Bourne, Y.,Zamboni, V.,Barre, A.,Peumans, W.J.,van Damme, E.J.M.,Rouge, P. (登録日: 1999-07-28, 公開日: 2000-01-10, 最終更新日: 2024-02-07)

主引用文献

Bourne, Y.,Zamboni, V.,Barre, A.,Peumans, W.J.,Van Damme, E.J.,Rouge, P.
Helianthus tuberosus lectin reveals a widespread scaffold for mannose-binding lectins.
Structure Fold.Des., 7:1473-1482, 1999

PubMed Abstract: Heltuba, a tuber lectin from the Jerusalem artichoke Helianthus tuberosus, belongs to the mannose-binding subgroup of the family of jacalin-related plant lectins. Heltuba is highly specific for the disaccharides Man alpha 1-3Man or Man alpha 1-2Man, two carbohydrates that are particularly abundant in the glycoconjugates exposed on the surface of viruses, bacteria and fungi, and on the epithelial cells along the gastrointestinal tract of lower animals. Heltuba is therefore a good candidate as a defense protein against plant pathogens or predators.

PubMed: 10647178
DOI: 10.1016/S0969-2126(00)88338-0

実験手法

X-RAY DIFFRACTION (2 Å)