Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1C3E

NEW INSIGHTS INTO INHIBITOR DESIGN FROM THE CRYSTAL STRUCTURE AND NMR STUDIES OF E. COLI GAR TRANSFORMYLATE IN COMPLEX WITH BETA-GAR AND 10-FORMYL-5,8,10-TRIDEAZAFOLIC ACID.

Summary for 1C3E
Entry DOI10.2210/pdb1c3e/pdb
Related1c2t
DescriptorGLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE, 2-{4-[2-(2-AMINO-4-HYDROXY-QUINAZOLIN-6-YL)-1-CARBOXY-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, GLYCINAMIDE RIBONUCLEOTIDE, ... (4 entities in total)
Functional Keywordspurine biosynthesis, anti-cancer agent, inhibitor complex, transferase
Biological sourceEscherichia coli
Total number of polymer chains2
Total formula weight47435.15
Authors
Greasley, S.E.,Yamashita, M.M.,Cai, H.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A. (deposition date: 1999-07-27, release date: 1999-12-29, Last modification date: 2024-02-07)
Primary citationGreasley, S.E.,Yamashita, M.M.,Cai, H.,Benkovic, S.J.,Boger, D.L.,Wilson, I.A.
New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid.
Biochemistry, 38:16783-16793, 1999
Cited by
PubMed: 10606510
DOI: 10.1021/bi991888a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

건을2024-03-27부터공개중

PDB statisticsPDBj update infoContact PDBjnumon