1BZS

CRYSTAL STRUCTURE OF MMP8 COMPLEXED WITH HMR2909

1BZS の概要

• エントリーDOI: 10.2210/pdb1bzs/pdb
• 分子名称: NEUTROPHIL COLLAGENASE, CALCIUM ION, ZINC ION, ... (6 entities in total)
• 機能のキーワード: metallo proteinase, hydroxamate, matrix degradation, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasmic granule: P22894
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19216.74

構造登録者

Schreuder, H.,Brachvogel, V.,Loenze, P. (登録日: 1998-11-04, 公開日: 2000-05-31, 最終更新日: 2023-08-09)

• 主引用文献: Matter, H.,Schwab, W.,Barbier, D.,Billen, G.,Haase, B.,Neises, B.,Schudok, M.,Thorwart, W.,Schreuder, H.,Brachvogel, V.,Lonze, P.,Weithmann, K.U.; Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis.; J.Med.Chem., 42:1908-1920, 1999; PubMed: 10354399; DOI: 10.1021/jm980631s

実験手法

X-RAY DIFFRACTION (1.7 Å)