1BZL

CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH TRYPANOTHIONE, AND THE STRUCTURE-BASED DISCOVERY OF NEW NATURAL PRODUCT INHIBITORS

1BZL の概要

• エントリーDOI: 10.2210/pdb1bzl/pdb
• 分子名称: TRYPANOTHIONE REDUCTASE (OXIDIZED FORM), FLAVIN-ADENINE DINUCLEOTIDE, BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, trypanothione reductase, fad dependent disulphide oxidoreductase
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 109632.76

構造登録者

Bond, C.S.,Zhang, Y.,Berriman, M.,Cunningham, M.,Fairlamb, A.H.,Hunter, W.N. (登録日: 1998-11-02, 公開日: 1999-11-10, 最終更新日: 2024-10-16)

主引用文献

Bond, C.S.,Zhang, Y.,Berriman, M.,Cunningham, M.L.,Fairlamb, A.H.,Hunter, W.N.
Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
Structure Fold.Des., 7:81-89, 1999

PubMed Abstract: Trypanothione reductase (TR) helps to maintain an intracellular reducing environment in trypanosomatids, a group of protozoan parasites that afflict humans and livestock in tropical areas. This protective function is achieved via reduction of polyamine-glutathione conjugates, in particular trypanothione. TR has been validated as a chemotherapeutic target by molecular genetics methods. To assist the development of new therapeutics, we have characterised the structure of TR from the pathogen Trypanosoma cruzi complexed with the substrate trypanothione and have used the structure to guide database searches and molecular modelling studies.

PubMed: 10368274
DOI: 10.1016/S0969-2126(99)80011-2

実験手法

X-RAY DIFFRACTION (2.4 Å)