1BZ9

CRYSTAL STRUCTURE OF MURINE CLASS I MHC H2-DB COMPLEXED WITH A SYNTHETIC PEPTIDE P1027

「1A9D」から置き換えられました

1BZ9 の概要

• エントリーDOI: 10.2210/pdb1bz9/pdb
• 分子名称: PROTEIN (CLASS I HISTOCOMPATIBILITY ANTIGEN), PROTEIN (PEPTIDE P1027 (FAPGVFPYM)), ... (4 entities in total)
• 機能のキーワード: murine class i mhc-peptide complex, murine class i mhc-peptide complex complex, murine class i mhc/peptide complex
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01899; Secreted: P01887
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45269.83

構造登録者

Zhao, R.,Collins, E.J. (登録日: 1998-11-06, 公開日: 1999-05-24, 最終更新日: 2024-10-30)

主引用文献

Zhao, R.,Loftus, D.J.,Appella, E.,Collins, E.J.
Structural evidence of T cell xeno-reactivity in the absence of molecular mimicry.
J.Exp.Med., 189:359-370, 1999

PubMed Abstract: The T cell receptor (TCR), from a xeno-reactive murine cytotoxic T lymphocyte clone AHIII12.2, recognizes murine H-2Db complexed with peptide p1027 (FAPGVFPYM), as well as human HLA-A2.1 complexed with peptide p1049 (ALWGFFPVL). A commonly proposed model (the molecular mimicry model) used to explain TCR cross-reactivity suggests that the molecular surfaces of the recognized complexes are similar in shape, charge, or both, in spite of the primary sequence differences. To examine the mechanism of xeno-reactivity of AHIII12.2, we have determined the crystal structures of A2/p1049 and Db/p1027 to 2.5 A and 2.8 A resolution, respectively. The crystal structures show that the TCR footprint regions of the two class I complexes are significantly different in shape and charge. We propose that rather than simple molecular mimicry, unpredictable arrays of common and differential contacts on the two class I complexes are used for their recognition by the same TCR.

PubMed: 9892618
DOI: 10.1084/jem.189.2.359

実験手法

X-RAY DIFFRACTION (2.8 Å)