1BXW

OUTER MEMBRANE PROTEIN A (OMPA) TRANSMEMBRANE DOMAIN

1BXW の概要

• エントリーDOI: 10.2210/pdb1bxw/pdb
• 分子名称: PROTEIN (OUTER MEMBRANE PROTEIN A), (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE (3 entities in total)
• 機能のキーワード: outer membrane, transmembrane protein, membrane protein
• 由来する生物種: Escherichia coli BL21(DE3)
• 細胞内の位置: Cell outer membrane ; Multi-pass membrane protein : P0A910
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19199.34

構造登録者

Schulz, G.E.,Pautsch, A. (登録日: 1998-10-03, 公開日: 1998-10-14, 最終更新日: 2024-05-22)

主引用文献

Pautsch, A.,Schulz, G.E.
Structure of the outer membrane protein A transmembrane domain.
Nat.Struct.Biol., 5:1013-1017, 1998

PubMed Abstract: The outer membrane protein A of Escherichia coli (OmpA) is an intensely studied example in the field of membrane protein folding. We have determined the structure of the OmpA transmembrane domain consisting of residues 1-171, by X-ray diffraction analysis, to a resolution of 2.5 A. It consists of a regular, extended eight-stranded beta-barrel and appears to be constructed like an inverse micelle with large water-filled cavities, but does not form a pore. Surprisingly, the cavities seem to be highly conserved during evolution. The structure corroborates the concept that all outer membrane proteins consist of beta-barrels. The structure constitutes a beta-barrel membrane anchor that appears to be the outer membrane equivalent of the single-chain alpha-helix anchor of the inner membrane.

PubMed: 9808047
DOI: 10.1038/2983

実験手法

X-RAY DIFFRACTION (2.5 Å)