1BXO
ACID PROTEINASE (PENICILLOPEPSIN) (E.C.3.4.23.20) COMPLEX WITH PHOSPHONATE INHIBITOR: METHYL CYCLO[(2S)-2-[[(1R)-1-(N-(L-N-(3-METHYLBUTANOYL)VALYL-L-ASPARTYL)AMINO)-3-METHYLBUT YL] HYDROXYPHOSPHINYLOXY]-3-(3-AMINOMETHYL) PHENYLPROPANOATE
Summary for 1BXO
Entry DOI | 10.2210/pdb1bxo/pdb |
Descriptor | PROTEIN (PENICILLOPEPSIN), alpha-D-mannopyranose, SULFATE ION, ... (6 entities in total) |
Functional Keywords | hydrolase, phosphonate inhibitors, macrocycle |
Biological source | Penicillium janthinellum |
Total number of polymer chains | 1 |
Total formula weight | 34748.06 |
Authors | Khan, A.R.,Parrish, J.C.,Fraser, M.E.,Smith, W.W.,Bartlett, P.A.,James, M.N.G. (deposition date: 1998-10-07, release date: 1998-10-14, Last modification date: 2023-08-09) |
Primary citation | Khan, A.R.,Parrish, J.C.,Fraser, M.E.,Smith, W.W.,Bartlett, P.A.,James, M.N. Lowering the entropic barrier for binding conformationally flexible inhibitors to enzymes. Biochemistry, 37:16839-16845, 1998 Cited by PubMed: 9836576DOI: 10.1021/bi9821364 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.95 Å) |
Structure validation
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