1BWG

DNA TRIPLEX WITH 5' AND 3' JUNCTIONS, NMR, 10 STRUCTURES

Summary for 1BWG

• Entry DOI: 10.2210/pdb1bwg/pdb
• Related: 1BCB 1BCE
• Descriptor: DNA (5'-D(*GP*AP*CP*TP*GP*AP*GP*AP*GP*AP*CP*GP*TP*A)-3'), DNA (5'-D(*TP*AP*CP*GP*TP*CP*TP*CP*TP*CP*AP*GP*TP*C)-3'), DNA (5'-D(*CP*TP*CP*TP*CP*T)-3') (3 entities in total)
• Functional Keywords: deoxyribonucleic acid, dna triplex, triplex-duplex junctions, dna
• Total number of polymer chains: 3
• Total formula weight: 10295.76

Authors

Asensio, J.L.,Brown, T.,Lane, A.N. (deposition date: 1998-09-22, release date: 1999-03-23, Last modification date: 2024-05-22)

Primary citation

Asensio, J.L.,Brown, T.,Lane, A.N.
Solution conformation of a parallel DNA triple helix with 5' and 3' triplex-duplex junctions.
Structure Fold.Des., 7:1-11, 1999

PubMed Abstract: Polypurine x polypyrimidine sequences of DNA can form parallel triple helices via Hoogsteen hydrogen bonds with a third DNA strand that is complementary to the purine strand. The triplex prevents transcription and could therefore potentially be used to regulate specific genes. The determination of the structures of triplex-duplex junctions can help us to understand the structural basis of specificity, and aid in the design of optimal antigene oligonucleotides.

PubMed: 10368268
DOI: 10.1016/S0969-2126(99)80004-5

Experimental method

SOLUTION NMR