1BWC
STRUCTURE OF HUMAN GLUTATHIONE REDUCTASE COMPLEXED with AJOENE INHIBITOR AND SUBVERSIVE SUBSTRATE
Summary for 1BWC
Entry DOI | 10.2210/pdb1bwc/pdb |
Descriptor | PROTEIN (GLUTATHIONE REDUCTASE), CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, flavoenzyme, redox-active center |
Biological source | Homo sapiens (human) |
Cellular location | Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390 |
Total number of polymer chains | 1 |
Total formula weight | 52619.52 |
Authors | Gallwitz, H.,Bonse, S.,Martinez-Cruz, A.,Schlichting, I.,Schumacher, K.,Krauth-Siegel, R.L. (deposition date: 1998-09-23, release date: 1999-07-20, Last modification date: 2023-08-09) |
Primary citation | Gallwitz, H.,Bonse, S.,Martinez-Cruz, A.,Schlichting, I.,Schumacher, K.,Krauth-Siegel, R.L. Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies. J.Med.Chem., 42:364-372, 1999 Cited by PubMed: 9986706DOI: 10.1021/jm980471k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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