1BWC

STRUCTURE OF HUMAN GLUTATHIONE REDUCTASE COMPLEXED with AJOENE INHIBITOR AND SUBVERSIVE SUBSTRATE

1BWC の概要

• エントリーDOI: 10.2210/pdb1bwc/pdb
• 分子名称: PROTEIN (GLUTATHIONE REDUCTASE), CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, flavoenzyme, redox-active center
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52619.52

構造登録者

Gallwitz, H.,Bonse, S.,Martinez-Cruz, A.,Schlichting, I.,Schumacher, K.,Krauth-Siegel, R.L. (登録日: 1998-09-23, 公開日: 1999-07-20, 最終更新日: 2023-08-09)

• 主引用文献: Gallwitz, H.,Bonse, S.,Martinez-Cruz, A.,Schlichting, I.,Schumacher, K.,Krauth-Siegel, R.L.; Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies.; J.Med.Chem., 42:364-372, 1999; PubMed: 9986706; DOI: 10.1021/jm980471k

実験手法