1BTZ

Episelection: novel KI ~nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface

1BTZ の概要

• エントリーDOI: 10.2210/pdb1btz/pdb
• 関連するPDBエントリー: 1btx 1bty
• 関連するBIRD辞書のPRD_ID: PRD_000390
• 分子名称: BETA-TRYPSIN, N-(tert-butoxycarbonyl)-L-alanyl-N-{(1R)-5-ammonio-1-[hydroxy(methoxy)boranyl]pentyl}-L-valinamide, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: tripeptideboronate methyl ester inhibited, serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted, extracellular space: P00760
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24484.39

構造登録者

Stroud, R.M.,Katz, B.A.,Finer-Moore, J. (登録日: 1995-05-17, 公開日: 1995-10-15, 最終更新日: 2012-12-12)

• 主引用文献: Katz, B.A.,Finer-Moore, J.,Mortezaei, R.,Rich, D.H.,Stroud, R.M.; Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.; Biochemistry, 34:8264-8280, 1995; PubMed: 7599119; DOI: 10.1021/bi00026a008

実験手法

X-RAY DIFFRACTION (2 Å)