1BQU
CYTOKYNE-BINDING REGION OF GP130
Summary for 1BQU
| Entry DOI | 10.2210/pdb1bqu/pdb |
| Descriptor | PROTEIN (GP130), SULFATE ION, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | cytokine receptor, glycoprotein 130, gp130, interleukine 6 receptor beta subunit, signaling protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P40189 |
| Total number of polymer chains | 2 |
| Total formula weight | 50298.02 |
| Authors | Bravo, J.,Staunton, D.,Heath, J.K.,Jones, E.Y. (deposition date: 1998-08-18, release date: 1998-08-26, Last modification date: 2022-12-21) |
| Primary citation | Bravo, J.,Staunton, D.,Heath, J.K.,Jones, E.Y. Crystal structure of a cytokine-binding region of gp130. EMBO J., 17:1665-1674, 1998 Cited by PubMed Abstract: The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain. PubMed: 9501088DOI: 10.1093/emboj/17.6.1665 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report
