1BQU

CYTOKYNE-BINDING REGION OF GP130

1BQU の概要

• エントリーDOI: 10.2210/pdb1bqu/pdb
• 分子名称: PROTEIN (GP130), SULFATE ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: cytokine receptor, glycoprotein 130, gp130, interleukine 6 receptor beta subunit, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P40189
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50298.02

構造登録者

Bravo, J.,Staunton, D.,Heath, J.K.,Jones, E.Y. (登録日: 1998-08-18, 公開日: 1998-08-26, 最終更新日: 2024-11-20)

主引用文献

Bravo, J.,Staunton, D.,Heath, J.K.,Jones, E.Y.
Crystal structure of a cytokine-binding region of gp130.
EMBO J., 17:1665-1674, 1998

PubMed Abstract: The structure of the cytokine-binding homology region of the cell surface receptor gp130 has been determined by X-ray crystallography at 2.0 A resolution. The beta sandwich structure of the two domains conforms to the topology of the cytokine receptor superfamily. This first structure of an uncomplexed receptor exhibits a similar L-shaped quaternary structure to that of ligand-bound family members and suggests a limited flexibility in relative domain orientation of some 3 degrees. The putative ligand-binding loops are relatively rigid, with a phenylalanine side chain similarly positioned to exposed aromatic residues implicated in ligand binding for other such receptors. The positioning and structure of the N-terminal portion of the polypeptide chain have implications for the structure and function of cytokine receptors, such as gp130, which contain an additional N-terminal immunoglobulin-like domain.

PubMed: 9501088
DOI: 10.1093/emboj/17.6.1665

実験手法

X-RAY DIFFRACTION (2 Å)