1BQO

DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS

Summary for 1BQO

Entry DOI	10.2210/pdb1bqo/pdb
Descriptor	STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	stromelysin, matrix metalloprotease, osteoarthritis, structure-based drug design, metalloprotease
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P08254
Total number of polymer chains	2
Total formula weight	39848.75
Authors	Pikul, S.,Dunham, K.L.M.,Almstead, N.G.,De, B.,Natchus, M.G.,Anastasio, M.V.,Mcphail, S.J.,Snider, C.E.,Taiwo, Y.O.,Rydel, T.J.,Dunaway, C.M.,Gu, F.,Mieling, G.E. (deposition date: 1998-08-17, release date: 1999-08-17, Last modification date: 2024-02-07)
Primary citation	Pikul, S.,McDow Dunham, K.L.,Almstead, N.G.,De, B.,Natchus, M.G.,Anastasio, M.V.,McPhail, S.J.,Snider, C.E.,Taiwo, Y.O.,Rydel, T.,Dunaway, C.M.,Gu, F.,Mieling, G.E. Discovery of potent, achiral matrix metalloproteinase inhibitors. J.Med.Chem., 41:3568-3571, 1998 Cited by PubMed: 9733482 DOI: 10.1021/jm980253r PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation