1BQO

DISCOVERY OF POTENT, ACHIRAL MATRIX METALLOPROTEINASE INHIBITORS

1BQO の概要

• エントリーDOI: 10.2210/pdb1bqo/pdb
• 分子名称: STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: stromelysin, matrix metalloprotease, osteoarthritis, structure-based drug design, metalloprotease
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix (Probable): P08254
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39848.75

構造登録者

Pikul, S.,Dunham, K.L.M.,Almstead, N.G.,De, B.,Natchus, M.G.,Anastasio, M.V.,Mcphail, S.J.,Snider, C.E.,Taiwo, Y.O.,Rydel, T.J.,Dunaway, C.M.,Gu, F.,Mieling, G.E. (登録日: 1998-08-17, 公開日: 1999-08-17, 最終更新日: 2024-02-07)

• 主引用文献: Pikul, S.,McDow Dunham, K.L.,Almstead, N.G.,De, B.,Natchus, M.G.,Anastasio, M.V.,McPhail, S.J.,Snider, C.E.,Taiwo, Y.O.,Rydel, T.,Dunaway, C.M.,Gu, F.,Mieling, G.E.; Discovery of potent, achiral matrix metalloproteinase inhibitors.; J.Med.Chem., 41:3568-3571, 1998; PubMed: 9733482; DOI: 10.1021/jm980253r

実験手法

X-RAY DIFFRACTION (2.3 Å)