1BQM

HIV-1 RT/HBY 097

1BQM の概要

• エントリーDOI: 10.2210/pdb1bqm/pdb
• 分子名称: REVERSE TRANSCRIPTASE, (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE (3 entities in total)
• 機能のキーワード: nucleotidyltransferase, aids, rna-directed dna polymerase, hiv-1 rt/hby 097, drug-resistant mutant
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114610.50

構造登録者

Hsiou, Y.,Das, K.,Ding, J.,Arnold, E. (登録日: 1998-08-17, 公開日: 1999-01-06, 最終更新日: 2023-08-09)

• 主引用文献: Hsiou, Y.,Das, K.,Ding, J.,Clark Jr., A.D.,Kleim, J.P.,Rosner, M.,Winkler, I.,Riess, G.,Hughes, S.H.,Arnold, E.; Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.; J.Mol.Biol., 284:313-323, 1998; PubMed: 9813120; DOI: 10.1006/jmbi.1998.2171

実験手法

X-RAY DIFFRACTION (3.1 Å)