1BPV

TITIN MODULE A71 FROM HUMAN CARDIAC MUSCLE, NMR, 50 STRUCTURES

1BPV の概要

• エントリーDOI: 10.2210/pdb1bpv/pdb
• 分子名称: TITIN (1 entity in total)
• 機能のキーワード: titin, connectin, fibronectin type iii
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12476.98

構造登録者

Muhle-Goll, C.,Pastore, A.,Nilges, M. (登録日: 1998-08-11, 公開日: 1999-08-12, 最終更新日: 2024-05-22)

主引用文献

Goll, C.M.,Pastore, A.,Nilges, M.
The three-dimensional structure of a type I module from titin: a prototype of intracellular fibronectin type III domains.
Structure, 6:1291-1302, 1998

PubMed Abstract: Titin is a huge protein ( approximately 3 MDa) that is present in the contractile unit (sarcomere) of striated muscle and has a key role in muscle assembly and elasticity. Titin is mainly composed of two types of module (type I and II). Type I modules are found exclusively in the region of titin localised in the A band, where they are arranged in a super-repeat pattern that correlates with the ultrastructure of the thick filament. No structure of a titin type I module has been reported so far.

PubMed: 9782056
DOI: 10.1016/S0969-2126(98)00129-4

実験手法

SOLUTION NMR