1BP6

THYMIDYLATE SYNTHASE R23I, R179T DOUBLE MUTANT

1BP6 の概要

• エントリーDOI: 10.2210/pdb1bp6/pdb
• 分子名称: PROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: transferase (methyltransferase), transferase, methyltransferase, nucleotide biosynthesis
• 由来する生物種: Lactobacillus casei
• 細胞内の位置: Cytoplasm: P00469
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36877.61

構造登録者

Morse, R.J.,Finer-Moore, J.S.,Stroud, R.M. (登録日: 1998-08-13, 公開日: 1998-08-19, 最終更新日: 2023-08-09)

• 主引用文献: Morse, R.J.,Kawase, S.,Santi, D.V.,Finer-Moore, J.,Stroud, R.M.; Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".; Biochemistry, 39:1011-1020, 2000; PubMed: 10653645; DOI: 10.1021/bi9918590

実験手法

X-RAY DIFFRACTION (2.4 Å)