1BP4

USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES.

1BP4 の概要

• エントリーDOI: 10.2210/pdb1bp4/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001210
• 分子名称: PAPAIN, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide (3 entities in total)
• 機能のキーワード: hydrolase, sulfhydryl proteinase
• 由来する生物種: Carica papaya (papaya)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23926.98

構造登録者

Lalonde, J.M.,Zhao, B.,Smith, W.W.,Janson, C.A.,Desjarlais, R.L.,Tomaszek, T.A.,Carr, T.J.,Thompson, S.K.,Yamashita, D.S.,Veber, D.F.,Abdel-Mequid, S.S. (登録日: 1998-08-12, 公開日: 1999-08-12, 最終更新日: 2023-08-09)

• 主引用文献: LaLonde, J.M.,Zhao, B.,Smith, W.W.,Janson, C.A.,DesJarlais, R.L.,Tomaszek, T.A.,Carr, T.J.,Thompson, S.K.,Oh, H.J.,Yamashita, D.S.,Veber, D.F.,Abdel-Meguid, S.S.; Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.; J.Med.Chem., 41:4567-4576, 1998; PubMed: 9804696; DOI: 10.1021/jm980249f

実験手法

X-RAY DIFFRACTION (2.2 Å)