1BM8

DNA-BINDING DOMAIN OF MBP1

Summary for 1BM8

• Entry DOI: 10.2210/pdb1bm8/pdb
• Descriptor: TRANSCRIPTION FACTOR MBP1 (2 entities in total)
• Functional Keywords: cell cycle, cyclins, dna synthesis, helix-turn-helix dna-binding domain, multiwavelength anomalous diffraction, transcription factor
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Nucleus: P39678
• Total number of polymer chains: 1
• Total formula weight: 11487.21

Authors

Xu, R.-M.,Koch, C.,Liu, Y.,Horton, J.R.,Knapp, D.,Nasmyth, K.,Cheng, X. (deposition date: 1998-07-29, release date: 1999-03-02, Last modification date: 2024-02-07)

Primary citation

Xu, R.M.,Koch, C.,Liu, Y.,Horton, J.R.,Knapp, D.,Nasmyth, K.,Cheng, X.
Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell-cycle control of DNA synthesis.
Structure, 5:349-358, 1997

PubMed Abstract: During the cell cycle, cells progress through four distinct phases, G1, S, G2 and M; transcriptional controls play an important role at the transition between these phases. MCB-binding factor (MBF), a transcription factor from budding yeast, binds to the so-called MCB (MluI cell-cycle box) elements found in the promoters of many DNA synthesis genes, and activates the transcription of those at the G1-->S phase transition. MBF is comprised of two proteins, Mbp1 and Swi6.

PubMed: 9083114
DOI: 10.1016/S0969-2126(97)00192-5

Experimental method

X-RAY DIFFRACTION (1.71 Å)