1BM2

GRB2-SH2 DOMAIN IN COMPLEX WITH CYCLO-[N-ALPHA-ACETYL-L-THI ALYSYL-O-PHOSPHOTYROSYL-VALYL-ASPARAGYL-VALYL-PROLYL] (PKF273-791)

1BM2 の概要

• エントリーDOI: 10.2210/pdb1bm2/pdb
• 分子名称: PROTEIN (GROWTH FACTOR RECEPTOR BOUND PROTEIN 2), PROTEIN (PKF273-791) (3 entities in total)
• 機能のキーワード: sh2 domain, signal transduction, adaptor protein, ras pathway, cyclic peptide, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 14420.26

構造登録者

Rondeau, J.M.,Zurini, M. (登録日: 1998-07-27, 公開日: 1998-08-05, 最終更新日: 2023-11-15)

• 主引用文献: Ettmayer, P.,France, D.,Gounarides, J.,Jarosinski, M.,Martin, M.S.,Rondeau, J.M.,Sabio, M.,Topiol, S.,Weidmann, B.,Zurini, M.,Bair, K.W.; Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).; J.Med.Chem., 42:971-980, 1999; PubMed: 10090780; DOI: 10.1021/jm9811007

実験手法

X-RAY DIFFRACTION (2.1 Å)