1BJI

THE X-RAY STRUCTURE OF A COMPLEX OF TERN N9 INFLUENZA VIRUS NEURAMINIDASE COMPLEXED WITH THE GLAXO 6-CARBOXAMIDE SIALIC ACID ANALOGUE GR217029

1BJI の概要

• エントリーDOI: 10.2210/pdb1bji/pdb
• 分子名称: NEURAMINIDASE, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ... (7 entities in total)
• 機能のキーワード: neuraminidase, influenza protein, inhibitor complex, 6-carboxamide derivative, sialic acid analogue, glaxo gr217029, hydrolase, glycoprotein
• 由来する生物種: Influenza A virus
• 細胞内の位置: Virion membrane (By similarity): P03472
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45848.83

構造登録者

Varghese, J.N. (登録日: 1997-12-03, 公開日: 1998-06-03, 最終更新日: 2024-04-03)

• 主引用文献: Taylor, N.R.,Cleasby, A.,Singh, O.,Skarzynski, T.,Wonacott, A.J.,Smith, P.W.,Sollis, S.L.,Howes, P.D.,Cherry, P.C.,Bethell, R.,Colman, P.,Varghese, J.; Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.; J.Med.Chem., 41:798-807, 1998; PubMed: 9526556; DOI: 10.1021/jm9703754

実験手法

X-RAY DIFFRACTION (2 Å)