1BIX

THE CRYSTAL STRUCTURE OF THE HUMAN DNA REPAIR ENDONUCLEASE HAP1 SUGGESTS THE RECOGNITION OF EXTRA-HELICAL DEOXYRIBOSE AT DNA ABASIC SITES

1BIX の概要

• エントリーDOI: 10.2210/pdb1bix/pdb
• 分子名称: AP ENDONUCLEASE 1, SAMARIUM (III) ION, PLATINUM (II) ION, ... (4 entities in total)
• 機能のキーワード: dna repair, endonuclease, hap1, ref-1, abasic site recognition
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus. DNA-(apurinic or apyrimidinic site) lyase, mitochondrial: Mitochondrion: P27695
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33084.20

構造登録者

Gorman, M.A.,Morera, S.,Rothwell, D.G.,De La Fortelle, E.,Mol, C.D.,Tainer, J.A.,Hickson, I.D.,Freemont, P.S. (登録日: 1998-06-19, 公開日: 1999-06-22, 最終更新日: 2024-02-07)

• 主引用文献: Gorman, M.A.,Morera, S.,Rothwell, D.G.,de La Fortelle, E.,Mol, C.D.,Tainer, J.A.,Hickson, I.D.,Freemont, P.S.; The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.; EMBO J., 16:6548-6558, 1997; PubMed: 9351835; DOI: 10.1093/emboj/16.21.6548

実験手法

X-RAY DIFFRACTION (2.2 Å)