1BIO

HUMAN COMPLEMENT FACTOR D IN COMPLEX WITH ISATOIC ANHYDRIDE INHIBITOR

Summary for 1BIO

Entry DOI	10.2210/pdb1bio/pdb
Descriptor	COMPLEMENT FACTOR D, ISATOIC ANHYDRIDE, GLYCEROL, ... (4 entities in total)
Functional Keywords	serine protease, hydrolase, complement, factor d, catalytic triad, self-regulation
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00746
Total number of polymer chains	1
Total formula weight	24654.05
Authors	Jing, H.,Babu, Y.S.,Moore, D.,Kilpatrick, J.M.,Liu, X.-Y.,Volanakis, J.E.,Narayana, S.V.L. (deposition date: 1998-06-18, release date: 1999-06-22, Last modification date: 2023-08-02)
Primary citation	Jing, H.,Babu, Y.S.,Moore, D.,Kilpatrick, J.M.,Liu, X.Y.,Volanakis, J.E.,Narayana, S.V. Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. J.Mol.Biol., 282:1061-1081, 1998 Cited by PubMed: 9753554 DOI: 10.1006/jmbi.1998.2089 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation