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1BIL

CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS

Summary for 1BIL
Entry DOI10.2210/pdb1bil/pdb
DescriptorRenin, (2S)-2-[(2-amino-1,3-thiazol-4-yl)methyl]-N~1~-[(1S,2R,3R)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-N~4~-[2-(d imethylamino)-2-oxoethyl]-N~4~-[(1S)-1-phenylethyl]butanediamide (3 entities in total)
Functional Keywordsaspartic proteinase, aspartyl protease, cleavage on pair of basic residues, disease mutation, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight75166.95
Authors
Tong, L. (deposition date: 1995-09-27, release date: 1996-01-29, Last modification date: 2022-03-09)
Primary citationTong, L.,Pav, S.,Lamarre, D.,Simoneau, B.,Lavallee, P.,Jung, G.
Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors.
J.Biol.Chem., 270:29520-29524, 1995
Cited by
PubMed: 7493993
DOI: 10.1074/jbc.270.49.29520
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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