1BHD

SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN

1BHD の概要

• エントリーDOI: 10.2210/pdb1bhd/pdb
• 分子名称: UTROPHIN (2 entities in total)
• 機能のキーワード: calponin homology, actin binding, structural protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side: P46939
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27357.36

構造登録者

Keep, N.H.,Winder, S.J.,Kendrick-Jones, J. (登録日: 1998-06-05, 公開日: 1999-01-13, 最終更新日: 2024-05-22)

主引用文献

Keep, N.H.,Norwood, F.L.,Moores, C.A.,Winder, S.J.,Kendrick-Jones, J.
The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin.
J.Mol.Biol., 285:1257-1264, 1999

PubMed Abstract: Utrophin is a close homologue of dystrophin, the protein defective in Duchenne muscular dystrophy. Like dystrophin, it is composed of three regions: an N-terminal region that binds actin filaments, a large central region with triple coiled-coil repeats, and a C-terminal region that interacts with components in the dystroglycan protein complex at the plasma membrane. The N-terminal actin-binding region consists of two calponin homology domains and is related to the actin-binding domains of a superfamily of proteins including alpha-actinin, spectrin and fimbrin. Here, we present the 2.0 A structure of the second calponin homology domain of utrophin solved by X-ray crystallography, and compare it to the other calponin homology domains previously determined from spectrin and fimbrin.

PubMed: 9887274
DOI: 10.1006/jmbi.1998.2406

実験手法

X-RAY DIFFRACTION (2 Å)