1BGY

CYTOCHROME BC1 COMPLEX FROM BOVINE

1BGY の概要

• エントリーDOI: 10.2210/pdb1bgy/pdb
• 分子名称: CYTOCHROME BC1 COMPLEX, PROTOPORPHYRIN IX CONTAINING FE, HEME C, ... (14 entities in total)
• 機能のキーワード: electron transport, cytochrome, membrane protein
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side: P31800 P23004; Mitochondrion inner membrane: P00130 P07552 P13272 P00129 P13271 P00126 P13272; Mitochondrion inner membrane; Multi-pass membrane protein (By similarity): P00157; Mitochondrion inner membrane; Single-pass membrane protein; Intermembrane side: P00125
• タンパク質・核酸の鎖数: 22
• 化学式量合計: 486151.20

構造登録者

Iwata, S.,Lee, J.W.,Okada, K.,Lee, J.K.,Iwata, M.,Ramaswamy, S.,Jap, B.K. (登録日: 1998-06-02, 公開日: 1999-01-06, 最終更新日: 2024-10-23)

主引用文献

Iwata, S.,Lee, J.W.,Okada, K.,Lee, J.K.,Iwata, M.,Rasmussen, B.,Link, T.A.,Ramaswamy, S.,Jap, B.K.
Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex.
Science, 281:64-71, 1998

PubMed Abstract: Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. Refined crystal structures of the 11-subunit bc1 complex from bovine heart reveal full views of this bifunctional enzyme. The "Rieske" iron-sulfur protein subunit shows significant conformational changes in different crystal forms, suggesting a new electron transport mechanism of the enzyme. The mitochondrial targeting presequence of the "Rieske" protein (subunit 9) is lodged between the two "core" subunits at the matrix side of the complex. These "core" subunits are related to the matrix processing peptidase, and the structure unveils how mitochondrial targeting presequences are recognized.

PubMed: 9651245
DOI: 10.1126/science.281.5373.64

実験手法

X-RAY DIFFRACTION (3 Å)