1BGW

TOPOISOMERASE RESIDUES 410-1202,

1BGW の概要

• エントリーDOI: 10.2210/pdb1bgw/pdb
• 分子名称: TOPOISOMERASE (2 entities in total)
• 機能のキーワード: isomerase, topoisomerase, dna-binding, phosphorylated nuclear protein, dna-binding protein, dna binding protein
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• 細胞内の位置: Nucleus: P06786
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 91810.60

構造登録者

Berger, J.M.,Gamblin, S.J.,Harrison, S.C.,Wang, J.C. (登録日: 1996-02-20, 公開日: 1996-07-11, 最終更新日: 2024-02-07)

主引用文献

Berger, J.M.,Gamblin, S.J.,Harrison, S.C.,Wang, J.C.
Structure and mechanism of DNA topoisomerase II.
Nature, 379:225-232, 1996

PubMed Abstract: The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.

PubMed: 8538787
DOI: 10.1038/379225a0

実験手法

X-RAY DIFFRACTION (2.7 Å)