1BGO
CRYSTAL STRUCTURE OF CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PEPTIDOMIMETIC INHIBITOR
Summary for 1BGO
Entry DOI | 10.2210/pdb1bgo/pdb |
Descriptor | CATHEPSIN K, 1-[2-(3-BIPHENYL)-4-METHYLVALERYL)]AMINO-3-(2-PYRIDYLSULFONYL)AMINO-2-PROPANONE (3 entities in total) |
Functional Keywords | hydrolase, sulfhydryl proteinase, thiol protease |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24005.09 |
Authors | Desjarlais, R.L.,Yamashita, D.S.,Oh, H.-J.,Bondinell, W.E.,Uzinskas, I.N.,Erhard, K.F.,Allen, A.C.,Haltiwanger, R.C.,Zhao, B.,Smith, W.W.,Abdel-Meguid, S.S.,D'Alessio, K.,Janson, C.A.,Mcqueney, M.S.,Tomaszek, T.A.,Levy, M.A.,Veber, D.F. (deposition date: 1998-05-29, release date: 1999-06-08, Last modification date: 2023-08-02) |
Primary citation | Desjarlais, R.L.,Yamashita, D.S.,Oh, H.J.,Uzinskas, I.N.,Erhard, K.F.,Allen, A.C.,Haltiwanger, R.C.,Zhao, B.G.,Smith, W.W.,Abdel-Meguid, S.S.,Dalessio, K.,Janson, C.A.,Mcqueney, M.S.,Tomaszek, T.A.,Levy, M.A.,Veber, D.F. Use of X-Ray Co-Crystal Structures and Molecular Modeling to Design Potent and Selective Non-Peptide Inhibitors of Cathepsin K J.Am.Chem.Soc., 120:9114-, 1998 Cited by |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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