1BG1

TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX

Summary for 1BG1

• Entry DOI: 10.2210/pdb1bg1/pdb
• Descriptor: DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), PROTEIN (TRANSCRIPTION FACTOR STAT3B) (3 entities in total)
• Functional Keywords: transcription factor, protein-dna complex, cytokine activation, complex (transcription factor-dna), transcription-dna complex, transcription/dna
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 73656.65

Authors

Becker, S.,Groner, B.,Muller, C.W. (deposition date: 1998-06-03, release date: 1999-01-13, Last modification date: 2024-10-30)

Primary citation

Becker, S.,Groner, B.,Muller, C.W.
Three-dimensional structure of the Stat3beta homodimer bound to DNA.
Nature, 394:145-151, 1998

PubMed Abstract: STAT proteins are a family of eukaryotic transcription factors that mediate the response to a large number of cytokines and growth factors. Upon activation by cell-surface receptors or their associated kinases, STAT proteins dimerize, translocate to the nucleus and bind to specific promoter sequences on their target genes. Here we report the first crystal structure of a STAT protein bound to its DNA recognition site at 2.25 A resolution. The structure provides insight into the various steps by which STAT proteins deliver a response signal directly from the cell membrane to their target genes in the nucleus.

PubMed: 9671298
DOI: 10.1038/28101

Experimental method

X-RAY DIFFRACTION (2.25 Å)