1BEH

HUMAN PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN IN COMPLEX WITH CACODYLATE

1BEH の概要

• エントリーDOI: 10.2210/pdb1beh/pdb
• 分子名称: PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN, CACODYLATE ION (3 entities in total)
• 機能のキーワード: lipid-binding, signalling, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42447.55

構造登録者

Banfield, M.J.,Barker, J.J.,Perry, A.,Brady, R.L. (登録日: 1998-05-14, 公開日: 1998-09-16, 最終更新日: 2024-05-22)

主引用文献

Banfield, M.J.,Barker, J.J.,Perry, A.C.,Brady, R.L.
Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction.
Structure, 6:1245-1254, 1998

PubMed Abstract: Proteins belonging to the phosphatidylethanolamine-binding protein (PEBP) family are highly conserved throughout nature and have no significant sequence homology with other proteins of known structure or function. A variety of biological roles have previously been described for members of this family, including lipid binding, roles as odorant effector molecules or opioids, interaction with the cell-signalling machinery, regulation of flowering plant stem architecture, and a function as a precursor protein of a bioactive brain neuropeptide. To date, no experimentally derived structural information has been available for this protein family. In this study we have used X-ray crystallography to determine the three-dimensional structure of human PEBP (hPEBP), in an attempt to clarify the biological role of this unique protein family.

PubMed: 9782050
DOI: 10.1016/S0969-2126(98)00125-7

実験手法

X-RAY DIFFRACTION (1.75 Å)