1BEC

BETA CHAIN OF A T CELL ANTIGEN RECEPTOR

1BEC の概要

• エントリーDOI: 10.2210/pdb1bec/pdb
• 分子名称: 14.3.D T CELL ANTIGEN RECEPTOR (2 entities in total)
• 機能のキーワード: t cell receptor, receptor
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26568.49

構造登録者

Bentley, G.A.,Boulot, G.,Karjalainen, K.,Mariuzza, R.A. (登録日: 1995-02-28, 公開日: 1995-10-25, 最終更新日: 2024-10-23)

主引用文献

Bentley, G.A.,Boulot, G.,Karjalainen, K.,Mariuzza, R.A.
Crystal structure of the beta chain of a T cell antigen receptor.
Science, 267:1984-1987, 1995

PubMed Abstract: The crystal structure of the extracellular portion of the beta chain of a murine T cell antigen receptor (TCR), determined at a resolution of 1.7 angstroms, shows structural homology to immunoglobulins. The structure of the first and second hypervariable loops suggested that, in general, they adopt more restricted sets of conformations in TCR beta chains than those found in immunoglobulins; the third hypervariable loop had certain structural characteristics in common with those of immunoglobulin heavy chain variable domains. The variable and constant domains were in close contact, presumably restricting the flexibility of the beta chain. This may facilitate signal transduction from the TCR to the associated CD3 molecules in the TCR-CD3 complex.

PubMed: 7701320

実験手法

X-RAY DIFFRACTION (1.7 Å)