1BDR
HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386
Summary for 1BDR
Entry DOI | 10.2210/pdb1bdr/pdb |
Descriptor | HIV-1 PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE (3 entities in total) |
Functional Keywords | hydrolase, aids, polyprotein, aspartyl protease, acid protease, hydroxyethylene isostere inhibitor, substrate analogue inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587 |
Total number of polymer chains | 2 |
Total formula weight | 21873.90 |
Authors | Swairjo, M.A.,Abdel-Meguid, S.S. (deposition date: 1998-05-10, release date: 1998-10-14, Last modification date: 2024-05-22) |
Primary citation | Swairjo, M.A.,Towler, E.M.,Debouck, C.,Abdel-Meguid, S.S. Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus protease. Biochemistry, 37:10928-10936, 1998 Cited by PubMed: 9692985DOI: 10.1021/bi980784h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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