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1BDR

HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386

Summary for 1BDR
Entry DOI10.2210/pdb1bdr/pdb
DescriptorHIV-1 PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE (3 entities in total)
Functional Keywordshydrolase, aids, polyprotein, aspartyl protease, acid protease, hydroxyethylene isostere inhibitor, substrate analogue inhibitor
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
Total number of polymer chains2
Total formula weight21873.90
Authors
Swairjo, M.A.,Abdel-Meguid, S.S. (deposition date: 1998-05-10, release date: 1998-10-14, Last modification date: 2023-08-02)
Primary citationSwairjo, M.A.,Towler, E.M.,Debouck, C.,Abdel-Meguid, S.S.
Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus protease.
Biochemistry, 37:10928-10936, 1998
Cited by
PubMed: 9692985
DOI: 10.1021/bi980784h
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

217705

數據於2024-03-27公開中

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