1BDR

HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386

1BDR の概要

• エントリーDOI: 10.2210/pdb1bdr/pdb
• 分子名称: HIV-1 PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE (3 entities in total)
• 機能のキーワード: hydrolase, aids, polyprotein, aspartyl protease, acid protease, hydroxyethylene isostere inhibitor, substrate analogue inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21873.90

構造登録者

Swairjo, M.A.,Abdel-Meguid, S.S. (登録日: 1998-05-10, 公開日: 1998-10-14, 最終更新日: 2023-08-02)

• 主引用文献: Swairjo, M.A.,Towler, E.M.,Debouck, C.,Abdel-Meguid, S.S.; Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus protease.; Biochemistry, 37:10928-10936, 1998; PubMed: 9692985; DOI: 10.1021/bi980784h

実験手法

X-RAY DIFFRACTION (2.8 Å)