1BDA

CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE)

Summary for 1BDA

Entry DOI	10.2210/pdb1bda/pdb
Related PRD ID	PRD_000413
Descriptor	SINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR, N-{[5-(dimethylamino)naphthalen-2-yl]sulfonyl}-L-alpha-glutamyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl) butyl]glycinamide (3 entities in total)
Functional Keywords	trypsin like serine protease, fibrinolytic enzymes, plasminogen activators, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space: P00750
Total number of polymer chains	2
Total formula weight	60705.57
Authors	Bode, W.,Renatus, M.,Engh, R.A. (deposition date: 1998-05-07, release date: 1999-05-11, Last modification date: 2023-08-02)
Primary citation	Renatus, M.,Engh, R.A.,Stubbs, M.T.,Huber, R.,Fischer, S.,Kohnert, U.,Bode, W. Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA. EMBO J., 16:4797-4805, 1997 Cited by PubMed: 9305622 DOI: 10.1093/emboj/16.16.4797 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.35 Å)

Structure validation