1BD2

COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201

1BD2 の概要

• エントリーDOI: 10.2210/pdb1bd2/pdb
• 分子名称: HLA-A 0201, BETA-2 MICROGLOBULIN, TAX PEPTIDE, ... (6 entities in total)
• 機能のキーワード: complex (mhc-viral peptide-receptor), complex (mhc-viral peptide-receptor) complex, complex (mhc/viral peptide/receptor)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted : P61769
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 94860.36

構造登録者

Ding, Y.-H.,Smith, K.J.,Garboczi, D.N.,Utz, U.,Biddison, W.E.,Wiley, D.C. (登録日: 1998-05-12, 公開日: 1998-08-19, 最終更新日: 2024-10-23)

主引用文献

Ding, Y.H.,Smith, K.J.,Garboczi, D.N.,Utz, U.,Biddison, W.E.,Wiley, D.C.
Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids.
Immunity, 8:403-411, 1998

PubMed Abstract: The three-dimensional structure of a human alphabeta T cell receptor (TCR), B7, bound to the HLA-A2 molecule/HTLV-1 Tax peptide complex was determined by x-ray crystallography. Although different from the A6 TCR, previously studied, in 16 of the 17 residues that contact HLA-A2/Tax, the B7 TCR binds in a similar diagonal manner, only slightly tipped and rotated, relative to the A6 TCR. The structure explains data from functional assays on the specificity differences between the B7 and A6 TCRs for agonist, partial agonist, and null peptides. The existence of a structurally similar diagonal binding mode for TCRs favors mechanisms based on the formation of geometrically defined supramolecular assemblies for initiating signaling.

PubMed: 9586631
DOI: 10.1016/S1074-7613(00)80546-4

実験手法

X-RAY DIFFRACTION (2.5 Å)