1B9W

C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI

1B9W の概要

• エントリーDOI: 10.2210/pdb1b9w/pdb
• 分子名称: PROTEIN (MEROZOITE SURFACE PROTEIN 1) (2 entities in total)
• 機能のキーワード: msp-1, candidate malaria vaccine, surface antigen, surface protein
• 由来する生物種: Plasmodium cynomolgi
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10795.19

構造登録者

Bentley, G.A.,Chitarra, V.,Holm, I.,Longacre, S. (登録日: 1999-02-15, 公開日: 1999-05-24, 最終更新日: 2024-10-09)

主引用文献

Chitarra, V.,Holm, I.,Bentley, G.A.,Petres, S.,Longacre, S.
The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A resolution, a highly protective malaria vaccine candidate.
Mol.Cell, 3:457-464, 1999

PubMed Abstract: The C-terminal proteolytic processing product of merozoite surface protein 1 (MSP1) appears essential for successful erythrocyte invasion by the malarial parasite, Plasmodium. We have determined the crystal structure at 1.8 A resolution of a soluble baculovirus-recombinant form of the protein from P. cynomolgi, which confers excellent protective efficacy in primate vaccination trials. The structure comprises two EGF-like domains, and sequence comparisons strongly suggest that the same conformation is present in all species of Plasmodium, including P. falciparum and P. vivax, which are pathogenic in man. In particular, conserved interdomain contacts between the two EGF modules should preserve the compact form of the molecule in all species. Implications of the crystal structure for anti-malarial vaccine development are discussed.

PubMed: 10230398
DOI: 10.1016/S1097-2765(00)80473-6

実験手法

X-RAY DIFFRACTION (1.8 Å)