1B9L

7,8-DIHYDRONEOPTERIN TRIPHOSPHATE EPIMERASE

1B9L の概要

• エントリーDOI: 10.2210/pdb1b9l/pdb
• 分子名称: PROTEIN (EPIMERASE) (1 entity in total)
• 機能のキーワード: epimerase, isomerase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 112824.19

構造登録者

Ploom, T.,Haussmann, C.,Hof, P.,Steinbacher, S.,Bacher, A.,Richardson, J.,Huber, R. (登録日: 1999-02-11, 公開日: 2000-02-18, 最終更新日: 2023-12-27)

主引用文献

Ploom, T.,Haussmann, C.,Hof, P.,Steinbacher, S.,Bacher, A.,Richardson, J.,Huber, R.
Crystal structure of 7,8-dihydroneopterin triphosphate epimerase.
Structure Fold.Des., 7:509-516, 1999

PubMed Abstract: Dihydroneopterin triphosphate (H2NTP) is the central substrate in the biosynthesis of folate and tetrahydrobiopterin. Folate serves as a cofactor in amino acid and purine biosynthesis and tetrahydrobiopterin is used as a cofactor in amino acid hydroxylation and nitric oxide synthesis. In bacteria, H2NTP enters the folate biosynthetic pathway after nonenzymatic dephosphorylation; in vertebrates, H2NTP is used to synthesize tetrahydrobiopterin. The dihydroneopterin triphosphate epimerase of Escherichia coli catalyzes the inversion of carbon 2' of H2NTP.

PubMed: 10378270
DOI: 10.1016/S0969-2126(99)80067-7

実験手法

X-RAY DIFFRACTION (2.9 Å)