1B87

CRYSTAL STRUCTURE OF AN AMINOGLYCOSIDE 6'-N-ACETYLTRANSFERASE

1B87 の概要

• エントリーDOI: 10.2210/pdb1b87/pdb
• 分子名称: PROTEIN (AMINOGLYCOSIDE N6'-ACETYLTRANSFERASE TYPE 1), ACETYL COENZYME *A (3 entities in total)
• 機能のキーワード: aminoglycoside 6'-n-acetyltransferase, antibiotic resistance, acetyl coenzyme a, transferase
• 由来する生物種: Enterococcus faecium
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21411.64

構造登録者

Wybenga-Groot, L.E.,Berghuis, A.M. (登録日: 1999-02-09, 公開日: 1999-06-30, 最終更新日: 2023-12-27)

主引用文献

Wybenga-Groot, L.E.,Draker, K.,Wright, G.D.,Berghuis, A.M.
Crystal structure of an aminoglycoside 6'-N-acetyltransferase: defining the GCN5-related N-acetyltransferase superfamily fold.
Structure Fold.Des., 7:497-507, 1999

PubMed Abstract: The predominant mechanism of antibiotic resistance employed by pathogenic bacteria against the clinically used aminoglycosides is chemical modification of the drug. The detoxification reactions are catalyzed by enzymes that promote either the phosphorylation, adenylation or acetylation of aminoglycosides. Structural studies of these aminoglycoside-modifying enzymes may assist in the development of therapeutic agents that could circumvent antibiotic resistance. In addition, such studies may shed light on the development of antibiotic resistance and the evolution of different enzyme classes.

PubMed: 10378269
DOI: 10.1016/S0969-2126(99)80066-5

実験手法

X-RAY DIFFRACTION (2.7 Å)