1B79

N-TERMINAL DOMAIN OF DNA REPLICATION PROTEIN DNAB

1B79 の概要

• エントリーDOI: 10.2210/pdb1b79/pdb
• 分子名称: DnaB Helicase (2 entities in total)
• 機能のキーワード: helicase, hexamer, dna replication, hydrolase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 52890.87

構造登録者

Fass, D.,Bogden, C.E.,Berger, J.M. (登録日: 1999-01-28, 公開日: 1999-06-30, 最終更新日: 2023-12-27)

主引用文献

Fass, D.,Bogden, C.E.,Berger, J.M.
Crystal structure of the N-terminal domain of the DnaB hexameric helicase.
Structure Fold.Des., 7:691-698, 1999

PubMed Abstract: The hexameric helicase DnaB unwinds the DNA duplex at the Escherichia coli chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a change in the quaternary structure of the protein involving dimerization of the N-terminal domain has been observed and may occur during the enzymatic cycle. This N-terminal domain is required both for interaction with other proteins in the primosome and for DnaB helicase activity. Knowledge of the structure of this domain may contribute to an understanding of its role in DnaB function.

PubMed: 10404598
DOI: 10.1016/S0969-2126(99)80090-2

実験手法

X-RAY DIFFRACTION (2.3 Å)