1B6Q

ALANINE 31 PROLINE MUTANT OF ROP PROTEIN

Summary for 1B6Q

• Entry DOI: 10.2210/pdb1b6q/pdb
• Descriptor: ROP (2 entities in total)
• Functional Keywords: transcription regulation
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 7263.08

Authors

Glykos, N.,Cesareni, G.,Kokkinidis, M. (deposition date: 1999-01-16, release date: 1999-07-09, Last modification date: 2024-05-22)

Primary citation

Glykos, N.M.,Cesareni, G.,Kokkinidis, M.
Protein plasticity to the extreme: changing the topology of a 4-alpha-helical bundle with a single amino acid substitution.
Structure Fold.Des., 7:597-603, 1999

PubMed Abstract: Conventional wisdom has it that two proteins sharing 98.4% sequence identity have nearly identical three-dimensional structures. Here we provide a counter-example to this statement by showing that a single amino acid substitution can change the topology of a homodimeric 4-alpha-helical bundle protein.

PubMed: 10404589
DOI: 10.1016/S0969-2126(99)80081-1

Experimental method

X-RAY DIFFRACTION (1.8 Å)