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1B6C

CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE TYPE I TGF-BETA RECEPTOR IN COMPLEX WITH FKBP12

1B6C の概要
エントリーDOI10.2210/pdb1b6c/pdb
分子名称FK506-BINDING PROTEIN, TGF-B SUPERFAMILY RECEPTOR TYPE I, SULFATE ION, ... (4 entities in total)
機能のキーワードcomplex (isomerase-protein kinase), receptor serine/threonine kinase, complex (isomerase-protein kinase) complex, complex (isomerase/protein kinase)
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Cytoplasm: P62942
Membrane; Single-pass type I membrane protein: P36897
タンパク質・核酸の鎖数8
化学式量合計203412.85
構造登録者
Huse, M.,Chen, Y.-G.,Massague, J.,Kuriyan, J. (登録日: 1999-01-13, 公開日: 1999-06-15, 最終更新日: 2024-02-07)
主引用文献Huse, M.,Chen, Y.G.,Massague, J.,Kuriyan, J.
Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12.
Cell(Cambridge,Mass.), 96:425-436, 1999
Cited by
PubMed Abstract: Activation of the type I TGFbeta receptor (TbetaR-I) requires phosphorylation of a regulatory segment known as the GS region, located upstream of the serine/threonine kinase domain in the cytoplasmic portion of the receptor. The crystal structure of a fragment of unphosphorylated TbetaR-I, containing both the GS region and the catalytic domain, has been determined in complex with the FK506-binding protein FKBP12. TbetaR-I adopts an inactive conformation that is maintained by the unphosphorylated GS region. FKBP12 binds to the GS region of the receptor, capping the TbetaR-II phosphorylation sites and further stabilizing the inactive conformation of TbetaR-I. Certain structural features at the catalytic center of TbetaR-I are characteristic of tyrosine kinases rather than Ser/Thr kinases.
PubMed: 10025408
DOI: 10.1016/S0092-8674(00)80555-3
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.6 Å)
構造検証レポート
Validation report summary of 1b6c
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-06-18に公開中

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