1B3N

BETA-KETOACYL CARRIER PROTEIN SYNTHASE AS A DRUG TARGET, IMPLICATIONS FROM THE CRYSTAL STRUCTURE OF A COMPLEX WITH THE INHIBITOR CERULENIN.

1B3N の概要

• エントリーDOI: 10.2210/pdb1b3n/pdb
• 分子名称: PROTEIN (KETOACYL ACYL CARRIER PROTEIN SYNTHASE 2), (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE (3 entities in total)
• 機能のキーワード: condensing enzymes, fatty acid elongation, cerulenin inhibition, lipid metabolism, drug design, drug target
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43183.72

構造登録者

Moche, M.,Schneider, G.,Edwards, P.,Dehesh, K.,Lindqvist, Y. (登録日: 1998-12-14, 公開日: 1999-04-06, 最終更新日: 2023-12-27)

• 主引用文献: Moche, M.,Schneider, G.,Edwards, P.,Dehesh, K.,Lindqvist, Y.; Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase.; J.Biol.Chem., 274:6031-6034, 1999; PubMed: 10037680; DOI: 10.1074/jbc.274.10.6031

実験手法

X-RAY DIFFRACTION (2.65 Å)