1B2W

COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY

Summary for 1B2W

Entry DOI	10.2210/pdb1b2w/pdb
Descriptor	PROTEIN (ANTIBODY (LIGHT CHAIN)), PROTEIN (ANTIBODY (HEAVY CHAIN)) (2 entities in total)
Functional Keywords	antibody engineering, humanized and chimeric antibody, fab, three-dimensional strycture, gamma-interferon, immune system
Biological source	Mus musculus, Homo sapiens More
Total number of polymer chains	2
Total formula weight	47231.68
Authors	Fan, Z.,Shan, L.,Goldsteen, B.Z.,Guddat, L.W.,Thakur, A.,Landolfi, N.F.,Co, M.S.,Vasquez, M.,Queen, C.,Ramsland, P.A.,Edmundson, A.B. (deposition date: 1998-12-01, release date: 1999-05-06, Last modification date: 2023-08-09)
Primary citation	Fan, Z.C.,Shan, L.,Goldsteen, B.Z.,Guddat, L.W.,Thakur, A.,Landolfi, N.F.,Co, M.S.,Vasquez, M.,Queen, C.,Ramsland, P.A.,Edmundson, A.B. Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody. J.Mol.Recog., 12:19-32, 1999 Cited by PubMed: 10398393 DOI: 10.1002/(SICI)1099-1352(199901/02)12:1<19::AID-JMR445>3.3.CO;2-P PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation