1AY6
THROMBIN INHIBITOR FROM THEONALLA, CYCLOTHEANAMIDE-BASED MACROCYCLIC TRIPEPTIDE MOTIF
Summary for 1AY6
Entry DOI | 10.2210/pdb1ay6/pdb |
Related PRD ID | PRD_000410 |
Descriptor | THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUGEN, ... (5 entities in total) |
Functional Keywords | complex of serine protease-inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P01050 |
Total number of polymer chains | 3 |
Total formula weight | 36098.17 |
Authors | Ganesh, V.,Maryanoff, B.E.,Tulinsky, A. (deposition date: 1997-11-14, release date: 1998-03-18, Last modification date: 2023-08-02) |
Primary citation | Greco, M.N.,Powell, E.T.,Hecker, L.R.,Andrade-Gordon, P.,Kauffman, J.A.,Lewis, J.M.,Ganesh, V.,Tulinsky, A.,Maryanoff, B.E. Novel thrombin inhibitors that are based on a macrocyclic tripeptide motif Bioorg.Med.Chem.Lett., 6:2947-2952, 1996 Cited by PubMed: 8367461DOI: 10.1016/S0960-894X(96)00554-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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